Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.

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Auteurs principaux: Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
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Accès en ligne:https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e
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Internet

https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e

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