Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.

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Autores principales: Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e
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spelling oai:doaj.org-article:094da27c385c4fb5be871715c40d5f4e2021-12-02T14:40:18ZBlood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy10.1038/s41467-019-11719-32041-1723https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11719-3https://doaj.org/toc/2041-1723Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.Anna GalstyanJanet L. MarkmanEkaterina S. ShatalovaAntonella ChiechiAlan J. KormanRameshwar PatilDmytro KlymyshynWarren G. TourtellotteLiron L. IsraelOliver BraubachVladimir A. LjubimovLeila A. MashoufArshia RameshZachary B. GrodzinskiManuel L. PenichetKeith L. BlackEggehard HollerTao SunHui DingAlexander V. LjubimovJulia Y. LjubimovaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anna Galstyan
Janet L. Markman
Ekaterina S. Shatalova
Antonella Chiechi
Alan J. Korman
Rameshwar Patil
Dmytro Klymyshyn
Warren G. Tourtellotte
Liron L. Israel
Oliver Braubach
Vladimir A. Ljubimov
Leila A. Mashouf
Arshia Ramesh
Zachary B. Grodzinski
Manuel L. Penichet
Keith L. Black
Eggehard Holler
Tao Sun
Hui Ding
Alexander V. Ljubimov
Julia Y. Ljubimova
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
description Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.
format article
author Anna Galstyan
Janet L. Markman
Ekaterina S. Shatalova
Antonella Chiechi
Alan J. Korman
Rameshwar Patil
Dmytro Klymyshyn
Warren G. Tourtellotte
Liron L. Israel
Oliver Braubach
Vladimir A. Ljubimov
Leila A. Mashouf
Arshia Ramesh
Zachary B. Grodzinski
Manuel L. Penichet
Keith L. Black
Eggehard Holler
Tao Sun
Hui Ding
Alexander V. Ljubimov
Julia Y. Ljubimova
author_facet Anna Galstyan
Janet L. Markman
Ekaterina S. Shatalova
Antonella Chiechi
Alan J. Korman
Rameshwar Patil
Dmytro Klymyshyn
Warren G. Tourtellotte
Liron L. Israel
Oliver Braubach
Vladimir A. Ljubimov
Leila A. Mashouf
Arshia Ramesh
Zachary B. Grodzinski
Manuel L. Penichet
Keith L. Black
Eggehard Holler
Tao Sun
Hui Ding
Alexander V. Ljubimov
Julia Y. Ljubimova
author_sort Anna Galstyan
title Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
title_short Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
title_full Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
title_fullStr Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
title_full_unstemmed Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
title_sort blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e
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