Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open sta...

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Autores principales: Panpan Hou, Jodene Eldstrom, Jingyi Shi, Ling Zhong, Kelli McFarland, Yuan Gao, David Fedida, Jianmin Cui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/095a5b4c60a9436bba52405c4ec9c56f
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