Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open sta...

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Autores principales:	Panpan Hou, Jodene Eldstrom, Jingyi Shi, Ling Zhong, Kelli McFarland, Yuan Gao, David Fedida, Jianmin Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/095a5b4c60a9436bba52405c4ec9c56f
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spelling	oai:doaj.org-article:095a5b4c60a9436bba52405c4ec9c56f2021-12-02T14:42:36ZInactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening10.1038/s41467-017-01911-82041-1723https://doaj.org/article/095a5b4c60a9436bba52405c4ec9c56f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01911-8https://doaj.org/toc/2041-1723KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open state, generating inactivation.Panpan HouJodene EldstromJingyi ShiLing ZhongKelli McFarlandYuan GaoDavid FedidaJianmin CuiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Panpan Hou Jodene Eldstrom Jingyi Shi Ling Zhong Kelli McFarland Yuan Gao David Fedida Jianmin Cui Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
description	KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open state, generating inactivation.
format	article
author	Panpan Hou Jodene Eldstrom Jingyi Shi Ling Zhong Kelli McFarland Yuan Gao David Fedida Jianmin Cui
author_facet	Panpan Hou Jodene Eldstrom Jingyi Shi Ling Zhong Kelli McFarland Yuan Gao David Fedida Jianmin Cui
author_sort	Panpan Hou
title	Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
title_short	Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
title_full	Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
title_fullStr	Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
title_full_unstemmed	Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
title_sort	inactivation of kcnq1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/095a5b4c60a9436bba52405c4ec9c56f
work_keys_str_mv	AT panpanhou inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT jodeneeldstrom inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT jingyishi inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT lingzhong inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT kellimcfarland inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT yuangao inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT davidfedida inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening AT jianmincui inactivationofkcnq1potassiumchannelsrevealsdynamiccouplingbetweenvoltagesensingandporeopening
_version_	1718389611219124224

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

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