Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage

Nicola Alessio,1,* Elisa Santoro,2,* Tiziana Squillaro,3 Domenico Aprile,1 Massimo Briccola,4 Paolo Giubbini,4 Raffaella Marchesani,4 Maria Rosaria Muoio,2 Monica Lamberti2 1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanv...

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Autores principales:	Alessio N, Santoro E, Squillaro T, Aprile D, Briccola M, Giubbini P, Marchesani R, Muoio MR, Lamberti M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	169 mhz stem cell senescence cfu Cytology QH573-671
Acceso en línea:	https://doaj.org/article/0998efba940541cf98e5c4d0bc7888ca
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spelling	oai:doaj.org-article:0998efba940541cf98e5c4d0bc7888ca2021-12-02T05:34:37ZLow-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage1178-6957https://doaj.org/article/0998efba940541cf98e5c4d0bc7888ca2019-12-01T00:00:00Zhttps://www.dovepress.com/low-level-radiofrequency-exposure-does-not-induce-changes-in-msc-biolo-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Nicola Alessio,1,* Elisa Santoro,2,* Tiziana Squillaro,3 Domenico Aprile,1 Massimo Briccola,4 Paolo Giubbini,4 Raffaella Marchesani,4 Maria Rosaria Muoio,2 Monica Lamberti2 1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Department of Experimental Medicine, Occupational Medicine Section, University of Campania "Luigi Vanvitelli", Naples, Italy; 3Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; 4e-distribuzione SpA, Rome, Italy*These authors contributed equally to this workCorrespondence: Nicola AlessioDepartment of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667585Fax +39 081 5667547Email nicola.alessio@yahoo.it Monica LambertiDepartment of Experimental Medicine, Occupational Medicine Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667731Email monica.lamberti@unicampania.itBackground: The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation.Purpose: The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30–300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity.Methods: The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G “Smart Meter” for different durations of time.Result: We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments.Conclusion: We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.Keywords: 169 MHz, stem cell, senescence, CFUAlessio NSantoro ESquillaro TAprile DBriccola MGiubbini PMarchesani RMuoio MRLamberti MDove Medical Pressarticle169 mhzstem cellsenescencecfuCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 12, Pp 49-59 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	169 mhz stem cell senescence cfu Cytology QH573-671
spellingShingle	169 mhz stem cell senescence cfu Cytology QH573-671 Alessio N Santoro E Squillaro T Aprile D Briccola M Giubbini P Marchesani R Muoio MR Lamberti M Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
description	Nicola Alessio,1,* Elisa Santoro,2,* Tiziana Squillaro,3 Domenico Aprile,1 Massimo Briccola,4 Paolo Giubbini,4 Raffaella Marchesani,4 Maria Rosaria Muoio,2 Monica Lamberti2 1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Department of Experimental Medicine, Occupational Medicine Section, University of Campania "Luigi Vanvitelli", Naples, Italy; 3Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; 4e-distribuzione SpA, Rome, Italy*These authors contributed equally to this workCorrespondence: Nicola AlessioDepartment of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667585Fax +39 081 5667547Email nicola.alessio@yahoo.it Monica LambertiDepartment of Experimental Medicine, Occupational Medicine Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667731Email monica.lamberti@unicampania.itBackground: The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation.Purpose: The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30–300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity.Methods: The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G “Smart Meter” for different durations of time.Result: We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments.Conclusion: We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.Keywords: 169 MHz, stem cell, senescence, CFU
format	article
author	Alessio N Santoro E Squillaro T Aprile D Briccola M Giubbini P Marchesani R Muoio MR Lamberti M
author_facet	Alessio N Santoro E Squillaro T Aprile D Briccola M Giubbini P Marchesani R Muoio MR Lamberti M
author_sort	Alessio N
title	Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
title_short	Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
title_full	Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
title_fullStr	Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
title_full_unstemmed	Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage
title_sort	low-level radiofrequency exposure does not induce changes in msc biology: an in vitro study for the prevention of nir-related damage
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0998efba940541cf98e5c4d0bc7888ca
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Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage

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