Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.

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Bibliographic Details
Main Authors: Tejas M. Gupte, Michael Ritt, Matthew Dysthe, Rabia U. Malik, Sivaraj Sivaramakrishnan
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/09a540a2a875492bb09d5e57994f67b2
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