Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.

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Autores principales:	Tejas M. Gupte, Michael Ritt, Matthew Dysthe, Rabia U. Malik, Sivaraj Sivaramakrishnan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09a540a2a875492bb09d5e57994f67b2
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spelling	oai:doaj.org-article:09a540a2a875492bb09d5e57994f67b22021-12-02T17:31:22ZMinute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling10.1038/s41467-019-12755-92041-1723https://doaj.org/article/09a540a2a875492bb09d5e57994f67b22019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12755-9https://doaj.org/toc/2041-1723Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.Tejas M. GupteMichael RittMatthew DystheRabia U. MalikSivaraj SivaramakrishnanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tejas M. Gupte Michael Ritt Matthew Dysthe Rabia U. Malik Sivaraj Sivaramakrishnan Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
description	Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.
format	article
author	Tejas M. Gupte Michael Ritt Matthew Dysthe Rabia U. Malik Sivaraj Sivaramakrishnan
author_facet	Tejas M. Gupte Michael Ritt Matthew Dysthe Rabia U. Malik Sivaraj Sivaramakrishnan
author_sort	Tejas M. Gupte
title	Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
title_short	Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
title_full	Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
title_fullStr	Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
title_full_unstemmed	Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
title_sort	minute-scale persistence of a gpcr conformation state triggered by non-cognate g protein interactions primes signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/09a540a2a875492bb09d5e57994f67b2
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Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

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