Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vert...

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Auteurs principaux: Sash Lopaticki, Annie S. P. Yang, Alan John, Nichollas E. Scott, James P. Lingford, Matthew T. O’Neill, Sara M. Erickson, Nicole C. McKenzie, Charlie Jennison, Lachlan W. Whitehead, Donna N. Douglas, Norman M. Kneteman, Ethan D. Goddard-Borger, Justin A. Boddey
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
Q
Accès en ligne:https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef
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Internet

https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef

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