Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vert...

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Autores principales:	Sash Lopaticki, Annie S. P. Yang, Alan John, Nichollas E. Scott, James P. Lingford, Matthew T. O’Neill, Sara M. Erickson, Nicole C. McKenzie, Charlie Jennison, Lachlan W. Whitehead, Donna N. Douglas, Norman M. Kneteman, Ethan D. Goddard-Borger, Justin A. Boddey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef
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spelling	oai:doaj.org-article:09e0a0fb76224df8a67b76f39e4a21ef2021-12-02T14:40:34ZProtein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts10.1038/s41467-017-00571-y2041-1723https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00571-yhttps://doaj.org/toc/2041-1723The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.Sash LopatickiAnnie S. P. YangAlan JohnNichollas E. ScottJames P. LingfordMatthew T. O’NeillSara M. EricksonNicole C. McKenzieCharlie JennisonLachlan W. WhiteheadDonna N. DouglasNorman M. KnetemanEthan D. Goddard-BorgerJustin A. BoddeyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sash Lopaticki Annie S. P. Yang Alan John Nichollas E. Scott James P. Lingford Matthew T. O’Neill Sara M. Erickson Nicole C. McKenzie Charlie Jennison Lachlan W. Whitehead Donna N. Douglas Norman M. Kneteman Ethan D. Goddard-Borger Justin A. Boddey Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
description	The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.
format	article
author	Sash Lopaticki Annie S. P. Yang Alan John Nichollas E. Scott James P. Lingford Matthew T. O’Neill Sara M. Erickson Nicole C. McKenzie Charlie Jennison Lachlan W. Whitehead Donna N. Douglas Norman M. Kneteman Ethan D. Goddard-Borger Justin A. Boddey
author_facet	Sash Lopaticki Annie S. P. Yang Alan John Nichollas E. Scott James P. Lingford Matthew T. O’Neill Sara M. Erickson Nicole C. McKenzie Charlie Jennison Lachlan W. Whitehead Donna N. Douglas Norman M. Kneteman Ethan D. Goddard-Borger Justin A. Boddey
author_sort	Sash Lopaticki
title	Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
title_short	Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
title_full	Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
title_fullStr	Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
title_full_unstemmed	Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
title_sort	protein o-fucosylation in plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef
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Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

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