A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly.

Alternative splicing of caspase-3 produces a short isoform caspase-3s that antagonizes caspase-3 apoptotic activity. However, the mechanism of apoptosis inhibition by caspase-3s remains unknown. Here we show that exogenous caspase-3 sensitizes MCF-7 and HBL100 breast cancers cells to chemotherapeuti...

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Autores principales: Frédérique Végran, Romain Boidot, Eric Solary, Sarab Lizard-Nacol
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/09e2da4b770b4dda8ed5d1c67c51d403
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