A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly.
Alternative splicing of caspase-3 produces a short isoform caspase-3s that antagonizes caspase-3 apoptotic activity. However, the mechanism of apoptosis inhibition by caspase-3s remains unknown. Here we show that exogenous caspase-3 sensitizes MCF-7 and HBL100 breast cancers cells to chemotherapeuti...
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Autores principales: | Frédérique Végran, Romain Boidot, Eric Solary, Sarab Lizard-Nacol |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/09e2da4b770b4dda8ed5d1c67c51d403 |
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