Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Exosomes are extracellular vesicles that can favor tumor development and metastasis. Here, the authors show that cancer exosomes may also exert a suppressive function; in fact, exosomes from non-metastatic melanoma cells can lead to the recruitment of patrolling monocytes, which clear cancer cells a...

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Autores principales:	Michael P. Plebanek, Nicholas L. Angeloni, Elena Vinokour, Jia Li, Anna Henkin, Dalia Martinez-Marin, Stephanie Filleur, Reshma Bhowmick, Jack Henkin, Stephen D. Miller, Igal Ifergan, Yesung Lee, Iman Osman, C. Shad Thaxton, Olga V. Volpert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a21f57d94e44252ad7ff8007fe02002
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spelling	oai:doaj.org-article:0a21f57d94e44252ad7ff8007fe020022021-12-02T14:42:18ZPre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche10.1038/s41467-017-01433-32041-1723https://doaj.org/article/0a21f57d94e44252ad7ff8007fe020022017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01433-3https://doaj.org/toc/2041-1723Exosomes are extracellular vesicles that can favor tumor development and metastasis. Here, the authors show that cancer exosomes may also exert a suppressive function; in fact, exosomes from non-metastatic melanoma cells can lead to the recruitment of patrolling monocytes, which clear cancer cells at the pre-metastatic niche.Michael P. PlebanekNicholas L. AngeloniElena VinokourJia LiAnna HenkinDalia Martinez-MarinStephanie FilleurReshma BhowmickJack HenkinStephen D. MillerIgal IferganYesung LeeIman OsmanC. Shad ThaxtonOlga V. VolpertNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael P. Plebanek Nicholas L. Angeloni Elena Vinokour Jia Li Anna Henkin Dalia Martinez-Marin Stephanie Filleur Reshma Bhowmick Jack Henkin Stephen D. Miller Igal Ifergan Yesung Lee Iman Osman C. Shad Thaxton Olga V. Volpert Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
description	Exosomes are extracellular vesicles that can favor tumor development and metastasis. Here, the authors show that cancer exosomes may also exert a suppressive function; in fact, exosomes from non-metastatic melanoma cells can lead to the recruitment of patrolling monocytes, which clear cancer cells at the pre-metastatic niche.
format	article
author	Michael P. Plebanek Nicholas L. Angeloni Elena Vinokour Jia Li Anna Henkin Dalia Martinez-Marin Stephanie Filleur Reshma Bhowmick Jack Henkin Stephen D. Miller Igal Ifergan Yesung Lee Iman Osman C. Shad Thaxton Olga V. Volpert
author_facet	Michael P. Plebanek Nicholas L. Angeloni Elena Vinokour Jia Li Anna Henkin Dalia Martinez-Marin Stephanie Filleur Reshma Bhowmick Jack Henkin Stephen D. Miller Igal Ifergan Yesung Lee Iman Osman C. Shad Thaxton Olga V. Volpert
author_sort	Michael P. Plebanek
title	Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
title_short	Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
title_full	Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
title_fullStr	Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
title_full_unstemmed	Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
title_sort	pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a21f57d94e44252ad7ff8007fe02002
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Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

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