Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity

Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity

Abstract The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosacch...

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Autores principales: Francesco Suriano, Laure B. Bindels, Joran Verspreet, Christophe M. Courtin, Kristin Verbeke, Patrice D. Cani, Audrey M. Neyrinck, Nathalie M. Delzenne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/0a21f7546f224f1898aee9107eed29ab
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spelling oai:doaj.org-article:0a21f7546f224f1898aee9107eed29ab2021-12-02T12:32:50ZFat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity10.1038/s41598-017-05698-y2045-2322https://doaj.org/article/0a21f7546f224f1898aee9107eed29ab2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05698-yhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression. AXOS was the most efficient to reduce adiposity. Only WB fraction promoted fat excretion and differed from the other fractions by the capacity to increase the Akkermansia genus and to counteract gut interleukin 1 beta (IL1β) overexpression. Strikingly, WBs promoted steatosis and adipose tissue inflammation, despite its ability -like WB- to increase bacterial diversity. In conclusion, wheat bran fractions differently affect metabolic and inflammatory disorders associated with WD feeding, depending on their particle size, their fat binding capacity and their influence on the gut microbiota. Those results might be useful to take into account in nutritional advices to control obesity.Francesco SurianoLaure B. BindelsJoran VerspreetChristophe M. CourtinKristin VerbekePatrice D. CaniAudrey M. NeyrinckNathalie M. DelzenneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Francesco Suriano
Laure B. Bindels
Joran Verspreet
Christophe M. Courtin
Kristin Verbeke
Patrice D. Cani
Audrey M. Neyrinck
Nathalie M. Delzenne
Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
description Abstract The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression. AXOS was the most efficient to reduce adiposity. Only WB fraction promoted fat excretion and differed from the other fractions by the capacity to increase the Akkermansia genus and to counteract gut interleukin 1 beta (IL1β) overexpression. Strikingly, WBs promoted steatosis and adipose tissue inflammation, despite its ability -like WB- to increase bacterial diversity. In conclusion, wheat bran fractions differently affect metabolic and inflammatory disorders associated with WD feeding, depending on their particle size, their fat binding capacity and their influence on the gut microbiota. Those results might be useful to take into account in nutritional advices to control obesity.
format article
author Francesco Suriano
Laure B. Bindels
Joran Verspreet
Christophe M. Courtin
Kristin Verbeke
Patrice D. Cani
Audrey M. Neyrinck
Nathalie M. Delzenne
author_facet Francesco Suriano
Laure B. Bindels
Joran Verspreet
Christophe M. Courtin
Kristin Verbeke
Patrice D. Cani
Audrey M. Neyrinck
Nathalie M. Delzenne
author_sort Francesco Suriano
title Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
title_short Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
title_full Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
title_fullStr Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
title_full_unstemmed Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
title_sort fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0a21f7546f224f1898aee9107eed29ab
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