Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation

Tropane alkaloids are medicinally significant plant metabolites generated by an unusual condensation of ornithine-derived and malonyl-CoA precursors. Here, Huang et al. show that pyrrolidine ketide synthase catalyzes a single round of condensation, which is followed by a non-enzymatic Mannich-like c...

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Auteurs principaux: Jian-Ping Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang, Sheng-Xiong Huang
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/0a4f26bf99364e4fb81db41d68738db7
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