Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation

Tropane alkaloids are medicinally significant plant metabolites generated by an unusual condensation of ornithine-derived and malonyl-CoA precursors. Here, Huang et al. show that pyrrolidine ketide synthase catalyzes a single round of condensation, which is followed by a non-enzymatic Mannich-like c...

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Autores principales:	Jian-Ping Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang, Sheng-Xiong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a4f26bf99364e4fb81db41d68738db7
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spelling	oai:doaj.org-article:0a4f26bf99364e4fb81db41d68738db72021-12-02T17:33:10ZTropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation10.1038/s41467-019-11987-z2041-1723https://doaj.org/article/0a4f26bf99364e4fb81db41d68738db72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11987-zhttps://doaj.org/toc/2041-1723Tropane alkaloids are medicinally significant plant metabolites generated by an unusual condensation of ornithine-derived and malonyl-CoA precursors. Here, Huang et al. show that pyrrolidine ketide synthase catalyzes a single round of condensation, which is followed by a non-enzymatic Mannich-like condensation.Jian-Ping HuangChengli FangXiaoyan MaLi WangJing YangJianying LuoYijun YanYu ZhangSheng-Xiong HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian-Ping Huang Chengli Fang Xiaoyan Ma Li Wang Jing Yang Jianying Luo Yijun Yan Yu Zhang Sheng-Xiong Huang Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
description	Tropane alkaloids are medicinally significant plant metabolites generated by an unusual condensation of ornithine-derived and malonyl-CoA precursors. Here, Huang et al. show that pyrrolidine ketide synthase catalyzes a single round of condensation, which is followed by a non-enzymatic Mannich-like condensation.
format	article
author	Jian-Ping Huang Chengli Fang Xiaoyan Ma Li Wang Jing Yang Jianying Luo Yijun Yan Yu Zhang Sheng-Xiong Huang
author_facet	Jian-Ping Huang Chengli Fang Xiaoyan Ma Li Wang Jing Yang Jianying Luo Yijun Yan Yu Zhang Sheng-Xiong Huang
author_sort	Jian-Ping Huang
title	Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
title_short	Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
title_full	Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
title_fullStr	Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
title_full_unstemmed	Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
title_sort	tropane alkaloids biosynthesis involves an unusual type iii polyketide synthase and non-enzymatic condensation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0a4f26bf99364e4fb81db41d68738db7
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Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation

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