Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

Abstract Indoxyl sulfate (IS) accumulates in the body in chronic kidney disease (CKD). In the renal proximal tubules, IS excretion is mediated by OAT1/3 and ABCG2. These transporters are inhibited by some hypouricemic agents; OATs by probenecid and benzbromarone, ABCG2 by febuxostat and benzbromaron...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tetsuya Taniguchi, Koichi Omura, Keisuke Motoki, Miku Sakai, Noriko Chikamatsu, Naoki Ashizawa, Tappei Takada, Takashi Iwanaga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/0a6860c1db1a4d4487fc7428387fc12b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!