Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.

Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling is critical to multiple cellular processes, including survival, differentiation, and proliferation. JAK-STAT signaling dysregulation has been noted in inflammatory disorders, and aberrant JAK2 pathway activation has...

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Autores principales: Jack W Singer, Suliman Al-Fayoumi, Jason Taylor, Sharlene Velichko, Alison O'Mahony
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2019
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Acceso en línea:https://doaj.org/article/0a6c4642fce44293bfd6aac30fb1e078
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