Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.

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Auteurs principaux: Zhi-Tao He, John F. Hartwig
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Q
Accès en ligne:https://doaj.org/article/0a82f86cdee2462bac4e2ef54fef7ea5
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