Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.

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Detalles Bibliográficos
Autores principales:	Zhi-Tao He, John F. Hartwig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a82f86cdee2462bac4e2ef54fef7ea5
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spelling	oai:doaj.org-article:0a82f86cdee2462bac4e2ef54fef7ea52021-12-02T15:35:18ZPalladium-catalyzed α-arylation for the addition of small rings to aromatic compounds10.1038/s41467-019-12090-z2041-1723https://doaj.org/article/0a82f86cdee2462bac4e2ef54fef7ea52019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12090-zhttps://doaj.org/toc/2041-1723Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.Zhi-Tao HeJohn F. HartwigNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi-Tao He John F. Hartwig Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
description	Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.
format	article
author	Zhi-Tao He John F. Hartwig
author_facet	Zhi-Tao He John F. Hartwig
author_sort	Zhi-Tao He
title	Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_short	Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_full	Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_fullStr	Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_full_unstemmed	Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_sort	palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0a82f86cdee2462bac4e2ef54fef7ea5
work_keys_str_mv	AT zhitaohe palladiumcatalyzedaarylationfortheadditionofsmallringstoaromaticcompounds AT johnfhartwig palladiumcatalyzedaarylationfortheadditionofsmallringstoaromaticcompounds
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Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

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