Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.

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Bibliographic Details
Main Authors: Zhi-Tao He, John F. Hartwig
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/0a82f86cdee2462bac4e2ef54fef7ea5
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