Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans

Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans

There is considerable inter-individual and inter-population variability in response to viruses. The potential of monocytes to elicit type-I interferon responses has attracted attention to their role in viral infections. Here, we use single-cell RNA-sequencing to characterize the role of cellular het...

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Auteurs principaux: Mary B. O’Neill, Hélène Quach, Julien Pothlichet, Yann Aquino, Aurélie Bisiaux, Nora Zidane, Matthieu Deschamps, Valentina Libri, Milena Hasan, Shen-Ying Zhang, Qian Zhang, Daniela Matuozzo, Aurélie Cobat, Laurent Abel, Jean-Laurent Casanova, Nadia Naffakh, Maxime Rotival, Lluis Quintana-Murci
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
Monocytes
single-cell ‘omics
transcriptomics
ancestry
population
influenza virus
Immunologic diseases. Allergy
RC581-607
Accès en ligne:https://doaj.org/article/0a9bfd47b5d7452aa289e2635dc3985a
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https://doaj.org/article/0a9bfd47b5d7452aa289e2635dc3985a

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