Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.

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Autores principales:	Chiharu Kimura-Yoshida, Kyoko Mochida, Masa-aki Nakaya, Takeomi Mizutani, Isao Matsuo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0aaadb922aff4943a14591e2ed41d58a
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spelling	oai:doaj.org-article:0aaadb922aff4943a14591e2ed41d58a2021-12-02T16:49:36ZCytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis10.1038/s41467-018-06171-82041-1723https://doaj.org/article/0aaadb922aff4943a14591e2ed41d58a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06171-8https://doaj.org/toc/2041-1723The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.Chiharu Kimura-YoshidaKyoko MochidaMasa-aki NakayaTakeomi MizutaniIsao MatsuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiharu Kimura-Yoshida Kyoko Mochida Masa-aki Nakaya Takeomi Mizutani Isao Matsuo Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
description	The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks.
format	article
author	Chiharu Kimura-Yoshida Kyoko Mochida Masa-aki Nakaya Takeomi Mizutani Isao Matsuo
author_facet	Chiharu Kimura-Yoshida Kyoko Mochida Masa-aki Nakaya Takeomi Mizutani Isao Matsuo
author_sort	Chiharu Kimura-Yoshida
title	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
title_short	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
title_full	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
title_fullStr	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
title_full_unstemmed	Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
title_sort	cytoplasmic localization of grhl3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0aaadb922aff4943a14591e2ed41d58a
work_keys_str_mv	AT chiharukimurayoshida cytoplasmiclocalizationofgrhl3uponepidermaldifferentiationtriggerscellshapechangeforepithelialmorphogenesis AT kyokomochida cytoplasmiclocalizationofgrhl3uponepidermaldifferentiationtriggerscellshapechangeforepithelialmorphogenesis AT masaakinakaya cytoplasmiclocalizationofgrhl3uponepidermaldifferentiationtriggerscellshapechangeforepithelialmorphogenesis AT takeomimizutani cytoplasmiclocalizationofgrhl3uponepidermaldifferentiationtriggerscellshapechangeforepithelialmorphogenesis AT isaomatsuo cytoplasmiclocalizationofgrhl3uponepidermaldifferentiationtriggerscellshapechangeforepithelialmorphogenesis
_version_	1718383258990804992

Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

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