Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature

Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature

Abstract Background Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of variants located in the cytotoxic T lymphocyte-associated protein-4 (CTLA4)-...

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Autores principales: Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning, Xu-jie Zhou
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Systemic lupus erythematosus
Single nucleotide polymorphisms
Immune checkpoint
CTLA4-ICOS
rs17268364
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/0ab8d93c84ba44f4954179dd23000152
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https://doaj.org/article/0ab8d93c84ba44f4954179dd23000152

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