Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature
Abstract Background Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of variants located in the cytotoxic T lymphocyte-associated protein-4 (CTLA4)-...
Guardado en:
Autores principales: | Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning, Xu-jie Zhou |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
BMC
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0ab8d93c84ba44f4954179dd23000152 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
CTLA-4 blockade in the treatment of colorectal cancer with microsatellite instability
por: Diana Russo, et al.
Publicado: (2021) -
Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy
por: Alimohammadi R, et al.
Publicado: (2020) -
INFLUENCE OF ANTIBODIES AGAINST CTLA-4 AND PD-1 UPON QUANTITIES OF THEIR TARGET RECEPTORS
por: I. O. Chikileva, et al.
Publicado: (2019) -
Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors Against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts
por: Yoshihide Suzuki, et al.
Publicado: (2021) -
CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
por: Chen Yan, et al.
Publicado: (2021)