A combination of p53-activating APR-246 and phosphatidylserine-targeting antibody potently inhibits tumor development in hormone-dependent mutant p53-expressing breast cancer xenografts
Yayun Liang,1 Benford Mafuvadze,1 Cynthia Besch-Williford,2 Salman M Hyder1 1Deparment of Biomedical Sciences and Dalton Cardiovascular Research Center, Columbia, MO, USA; 2IDEXX BioResearch, Columbia, MO, USA Background: Between 30 and 40% of human breast cancers express a defective tumor suppresso...
Guardado en:
Autores principales: | Liang Y, Mafuvadze B, Besch-Williford C, Hyder SM |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0acb0cb4cb3941b5afe2ed4d44ac85de |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice
por: Liang Y, et al.
Publicado: (2019) -
Complexes formed by mutant p53 and their roles in breast cancer
por: Bellazzo A, et al.
Publicado: (2018) -
Redox Sensitive Cysteine Residues as Crucial Regulators of Wild-Type and Mutant p53 Isoforms
por: Elena Butturini, et al.
Publicado: (2021) -
p53 e as hemopatias malignas
por: Geraldo Barroso Cavalcanti Júnior, et al.
Publicado: (2002) -
Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246
por: Lena Haffo, et al.
Publicado: (2018)