Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level

Synaptic plasticity is the neuronal mechanism underlying learning. Here the authors construct biophysical models of pyramidal neurons that reproduce observed plasticity gradients along the dendrite and show that dendritic spike dependent LTP which is predominant in distal sections can prolong memory...

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Autores principales:	Jacopo Bono, Claudia Clopath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0af9b233961047b491c6c3764c9c1f42
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spelling	oai:doaj.org-article:0af9b233961047b491c6c3764c9c1f422021-12-02T14:40:25ZModeling somatic and dendritic spike mediated plasticity at the single neuron and network level10.1038/s41467-017-00740-z2041-1723https://doaj.org/article/0af9b233961047b491c6c3764c9c1f422017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00740-zhttps://doaj.org/toc/2041-1723Synaptic plasticity is the neuronal mechanism underlying learning. Here the authors construct biophysical models of pyramidal neurons that reproduce observed plasticity gradients along the dendrite and show that dendritic spike dependent LTP which is predominant in distal sections can prolong memory retention.Jacopo BonoClaudia ClopathNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacopo Bono Claudia Clopath Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
description	Synaptic plasticity is the neuronal mechanism underlying learning. Here the authors construct biophysical models of pyramidal neurons that reproduce observed plasticity gradients along the dendrite and show that dendritic spike dependent LTP which is predominant in distal sections can prolong memory retention.
format	article
author	Jacopo Bono Claudia Clopath
author_facet	Jacopo Bono Claudia Clopath
author_sort	Jacopo Bono
title	Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
title_short	Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
title_full	Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
title_fullStr	Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
title_full_unstemmed	Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
title_sort	modeling somatic and dendritic spike mediated plasticity at the single neuron and network level
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0af9b233961047b491c6c3764c9c1f42
work_keys_str_mv	AT jacopobono modelingsomaticanddendriticspikemediatedplasticityatthesingleneuronandnetworklevel AT claudiaclopath modelingsomaticanddendriticspikemediatedplasticityatthesingleneuronandnetworklevel
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Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level

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