Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

It is unclear whether fallopian tube epithelium or ovarian surface epithelium is the cell-of-origin of high grade serous ovarian carcinoma (HGSOC). Here the authors report a dualistic origin for HGSOC using genetically engineered mouse models and observe differential chemotherapy sensitivity dependi...

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Bibliographic Details
Main Authors: Shuang Zhang, Igor Dolgalev, Tao Zhang, Hao Ran, Douglas A. Levine, Benjamin G. Neel
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/0b39734610e54645b1f1c0d284b8d77c
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