Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

It is unclear whether fallopian tube epithelium or ovarian surface epithelium is the cell-of-origin of high grade serous ovarian carcinoma (HGSOC). Here the authors report a dualistic origin for HGSOC using genetically engineered mouse models and observe differential chemotherapy sensitivity dependi...

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Autores principales:	Shuang Zhang, Igor Dolgalev, Tao Zhang, Hao Ran, Douglas A. Levine, Benjamin G. Neel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b39734610e54645b1f1c0d284b8d77c
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spelling	oai:doaj.org-article:0b39734610e54645b1f1c0d284b8d77c2021-12-02T17:01:45ZBoth fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma10.1038/s41467-019-13116-22041-1723https://doaj.org/article/0b39734610e54645b1f1c0d284b8d77c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13116-2https://doaj.org/toc/2041-1723It is unclear whether fallopian tube epithelium or ovarian surface epithelium is the cell-of-origin of high grade serous ovarian carcinoma (HGSOC). Here the authors report a dualistic origin for HGSOC using genetically engineered mouse models and observe differential chemotherapy sensitivity depending on the cell-of-origin.Shuang ZhangIgor DolgalevTao ZhangHao RanDouglas A. LevineBenjamin G. NeelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuang Zhang Igor Dolgalev Tao Zhang Hao Ran Douglas A. Levine Benjamin G. Neel Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
description	It is unclear whether fallopian tube epithelium or ovarian surface epithelium is the cell-of-origin of high grade serous ovarian carcinoma (HGSOC). Here the authors report a dualistic origin for HGSOC using genetically engineered mouse models and observe differential chemotherapy sensitivity depending on the cell-of-origin.
format	article
author	Shuang Zhang Igor Dolgalev Tao Zhang Hao Ran Douglas A. Levine Benjamin G. Neel
author_facet	Shuang Zhang Igor Dolgalev Tao Zhang Hao Ran Douglas A. Levine Benjamin G. Neel
author_sort	Shuang Zhang
title	Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
title_short	Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
title_full	Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
title_fullStr	Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
title_full_unstemmed	Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
title_sort	both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0b39734610e54645b1f1c0d284b8d77c
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Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

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