Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation

Although proliferation of keratinocytes, a major type of skin cells, is a key factor in maintaining the function of skin, their ability to proliferate tends to diminish with age. To solve such a problem, researchers in medical and skin cosmetic fields have tried to utilize epidermal growth factor (E...

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Autores principales:	Paul Kwangho Kwon, Sung Wook Kim, Ranjit De, Sung Woo Jeong, Kyong-Tai Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	EGFR signaling natural compound isoprocurcumenol keratinocyte wound healing Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0b55ffbd73944dc6a42dc0163d29f868
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spelling	oai:doaj.org-article:0b55ffbd73944dc6a42dc0163d29f8682021-11-25T17:58:06ZIsoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation10.3390/ijms2222125791422-00671661-6596https://doaj.org/article/0b55ffbd73944dc6a42dc0163d29f8682021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12579https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Although proliferation of keratinocytes, a major type of skin cells, is a key factor in maintaining the function of skin, their ability to proliferate tends to diminish with age. To solve such a problem, researchers in medical and skin cosmetic fields have tried to utilize epidermal growth factor (EGF), but achieved limited success. Therefore, a small natural compound that can mimic the activity of EGF is highly desired in both medical and cosmetic fields. Here, using the modified biosensor system, we observed that natural small-compound isoprocurcumenol, which is a terpenoid molecule derived from turmeric, can activate EGFR signaling. It increased the phosphorylation of ERK and AKT, and upregulated the expression of genes related to cell growth and proliferation, such as <i>c-myc</i>, <i>c-jun</i>, <i>c-fos</i>, and <i>egr-1</i>. In addition, isoprocurcumenol induced the proliferation of keratinocytes in both physical and UVB-induced cellular damage, indicative of its function in skin regeneration. These findings reveal that EGF-like isoprocurcumenol promotes the proliferation of keratinocytes and further suggest its potential as an ingredient for medical and cosmetics use.Paul Kwangho KwonSung Wook KimRanjit DeSung Woo JeongKyong-Tai KimMDPI AGarticleEGFR signalingnatural compoundisoprocurcumenolkeratinocytewound healingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12579, p 12579 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	EGFR signaling natural compound isoprocurcumenol keratinocyte wound healing Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	EGFR signaling natural compound isoprocurcumenol keratinocyte wound healing Biology (General) QH301-705.5 Chemistry QD1-999 Paul Kwangho Kwon Sung Wook Kim Ranjit De Sung Woo Jeong Kyong-Tai Kim Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
description	Although proliferation of keratinocytes, a major type of skin cells, is a key factor in maintaining the function of skin, their ability to proliferate tends to diminish with age. To solve such a problem, researchers in medical and skin cosmetic fields have tried to utilize epidermal growth factor (EGF), but achieved limited success. Therefore, a small natural compound that can mimic the activity of EGF is highly desired in both medical and cosmetic fields. Here, using the modified biosensor system, we observed that natural small-compound isoprocurcumenol, which is a terpenoid molecule derived from turmeric, can activate EGFR signaling. It increased the phosphorylation of ERK and AKT, and upregulated the expression of genes related to cell growth and proliferation, such as <i>c-myc</i>, <i>c-jun</i>, <i>c-fos</i>, and <i>egr-1</i>. In addition, isoprocurcumenol induced the proliferation of keratinocytes in both physical and UVB-induced cellular damage, indicative of its function in skin regeneration. These findings reveal that EGF-like isoprocurcumenol promotes the proliferation of keratinocytes and further suggest its potential as an ingredient for medical and cosmetics use.
format	article
author	Paul Kwangho Kwon Sung Wook Kim Ranjit De Sung Woo Jeong Kyong-Tai Kim
author_facet	Paul Kwangho Kwon Sung Wook Kim Ranjit De Sung Woo Jeong Kyong-Tai Kim
author_sort	Paul Kwangho Kwon
title	Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
title_short	Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
title_full	Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
title_fullStr	Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
title_full_unstemmed	Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation
title_sort	isoprocurcumenol supports keratinocyte growth and survival through epidermal growth factor receptor activation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0b55ffbd73944dc6a42dc0163d29f868
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Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation

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