β-Glucuronidases of opportunistic bacteria are the major contributors to xenobiotic-induced toxicity in the gut

Abstract Gut bacterial β-D-glucuronidases (GUSs) catalyze the removal of glucuronic acid from liver-produced β-D-glucuronides. These reactions can have deleterious consequences when they reverse xenobiotic metabolism. The human gut contains hundreds of GUSs of variable sequences and structures. To u...

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Autores principales: Punsaldulam Dashnyam, Ramesh Mudududdla, Tung-Ju Hsieh, Ting-Chien Lin, Hsien-Ya Lin, Peng-Yuan Chen, Chia-Yi Hsu, Chun-Hung Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0b6371ff0cd6400d83e8e0397189f8c8
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