Independent control of the thermodynamic and kinetic properties of aptamer switches

Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.

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Bibliographic Details
Main Authors: Brandon D. Wilson, Amani A. Hariri, Ian A. P. Thompson, Michael Eisenstein, H. Tom Soh
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/0ba91a767197432caebcff4ce0b2b98c
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