Independent control of the thermodynamic and kinetic properties of aptamer switches

Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.

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Autores principales:	Brandon D. Wilson, Amani A. Hariri, Ian A. P. Thompson, Michael Eisenstein, H. Tom Soh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ba91a767197432caebcff4ce0b2b98c
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spelling	oai:doaj.org-article:0ba91a767197432caebcff4ce0b2b98c2021-12-02T15:35:49ZIndependent control of the thermodynamic and kinetic properties of aptamer switches10.1038/s41467-019-13137-x2041-1723https://doaj.org/article/0ba91a767197432caebcff4ce0b2b98c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13137-xhttps://doaj.org/toc/2041-1723Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.Brandon D. WilsonAmani A. HaririIan A. P. ThompsonMichael EisensteinH. Tom SohNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon D. Wilson Amani A. Hariri Ian A. P. Thompson Michael Eisenstein H. Tom Soh Independent control of the thermodynamic and kinetic properties of aptamer switches
description	Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.
format	article
author	Brandon D. Wilson Amani A. Hariri Ian A. P. Thompson Michael Eisenstein H. Tom Soh
author_facet	Brandon D. Wilson Amani A. Hariri Ian A. P. Thompson Michael Eisenstein H. Tom Soh
author_sort	Brandon D. Wilson
title	Independent control of the thermodynamic and kinetic properties of aptamer switches
title_short	Independent control of the thermodynamic and kinetic properties of aptamer switches
title_full	Independent control of the thermodynamic and kinetic properties of aptamer switches
title_fullStr	Independent control of the thermodynamic and kinetic properties of aptamer switches
title_full_unstemmed	Independent control of the thermodynamic and kinetic properties of aptamer switches
title_sort	independent control of the thermodynamic and kinetic properties of aptamer switches
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ba91a767197432caebcff4ce0b2b98c
work_keys_str_mv	AT brandondwilson independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches AT amaniahariri independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches AT ianapthompson independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches AT michaeleisenstein independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches AT htomsoh independentcontrolofthethermodynamicandkineticpropertiesofaptamerswitches
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Independent control of the thermodynamic and kinetic properties of aptamer switches

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