Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Transposable elements are a potential source of transcriptional regulators, but how these sequences contribute to oncogenesis remains poorly understood. Here, the authors identify endogenous retroviruses (ERVs) with acute myeloid leukemia (AML)-associated enhancer chromatin signatures, and provide e...

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Autores principales: Özgen Deniz, Mamataz Ahmed, Christopher D. Todd, Ana Rio-Machin, Mark A. Dawson, Miguel R. Branco
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0bf877e599a4400dbac6a8a802ed554f
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