Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Transposable elements are a potential source of transcriptional regulators, but how these sequences contribute to oncogenesis remains poorly understood. Here, the authors identify endogenous retroviruses (ERVs) with acute myeloid leukemia (AML)-associated enhancer chromatin signatures, and provide e...

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Autores principales:	Özgen Deniz, Mamataz Ahmed, Christopher D. Todd, Ana Rio-Machin, Mark A. Dawson, Miguel R. Branco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0bf877e599a4400dbac6a8a802ed554f
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spelling	oai:doaj.org-article:0bf877e599a4400dbac6a8a802ed554f2021-12-02T17:01:30ZEndogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia10.1038/s41467-020-17206-42041-1723https://doaj.org/article/0bf877e599a4400dbac6a8a802ed554f2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17206-4https://doaj.org/toc/2041-1723Transposable elements are a potential source of transcriptional regulators, but how these sequences contribute to oncogenesis remains poorly understood. Here, the authors identify endogenous retroviruses (ERVs) with acute myeloid leukemia (AML)-associated enhancer chromatin signatures, and provide evidence that ERV activation provides an additional layer of gene regulation in AML.Özgen DenizMamataz AhmedChristopher D. ToddAna Rio-MachinMark A. DawsonMiguel R. BrancoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Özgen Deniz Mamataz Ahmed Christopher D. Todd Ana Rio-Machin Mark A. Dawson Miguel R. Branco Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
description	Transposable elements are a potential source of transcriptional regulators, but how these sequences contribute to oncogenesis remains poorly understood. Here, the authors identify endogenous retroviruses (ERVs) with acute myeloid leukemia (AML)-associated enhancer chromatin signatures, and provide evidence that ERV activation provides an additional layer of gene regulation in AML.
format	article
author	Özgen Deniz Mamataz Ahmed Christopher D. Todd Ana Rio-Machin Mark A. Dawson Miguel R. Branco
author_facet	Özgen Deniz Mamataz Ahmed Christopher D. Todd Ana Rio-Machin Mark A. Dawson Miguel R. Branco
author_sort	Özgen Deniz
title	Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
title_short	Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
title_full	Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
title_fullStr	Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
title_full_unstemmed	Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
title_sort	endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0bf877e599a4400dbac6a8a802ed554f
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Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

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