Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells
ADAM17 is upregulated in many cancers and in turn activates signaling pathways, including EGFR/ErbB, as well as those underlying resistance to targeted anti-EGFR therapies. Due to its central role in oncogenic pathways and drug resistance mechanisms, specific and efficacious monoclonal antibodies ag...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Elsevier
2022
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/0c1537a2f183403bbaf393d83c36b312 |
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