An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucose levels, providing a link between cholesterol lev...

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Autores principales:	Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
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spelling	oai:doaj.org-article:0c2afd1828064aad921b2b15f3e5c1e22021-12-02T10:49:32ZAn integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease10.1038/s41467-020-20750-82041-1723https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20750-8https://doaj.org/toc/2041-1723Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucose levels, providing a link between cholesterol levels and diabetes.Ariella T. CohainWilliam T. BarringtonDaniel M. JordanNoam D. BeckmannCarmen A. ArgmannSander M. HoutenAlexander W. CharneyRaili ErmelKatyayani SukhavasiOscar FranzenSimon KoplevCarl WhatlingGillian M. BelbinJialiang YangKe HaoEimear E. KennyZhidong TuJun ZhuLi-Ming GanRon DoChiara GiannarelliJason C. KovacicArno RuusaleppAldons J. LusisJohan L. M. BjorkegrenEric E. SchadtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ariella T. Cohain William T. Barrington Daniel M. Jordan Noam D. Beckmann Carmen A. Argmann Sander M. Houten Alexander W. Charney Raili Ermel Katyayani Sukhavasi Oscar Franzen Simon Koplev Carl Whatling Gillian M. Belbin Jialiang Yang Ke Hao Eimear E. Kenny Zhidong Tu Jun Zhu Li-Ming Gan Ron Do Chiara Giannarelli Jason C. Kovacic Arno Ruusalepp Aldons J. Lusis Johan L. M. Bjorkegren Eric E. Schadt An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
description	Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucose levels, providing a link between cholesterol levels and diabetes.
format	article
author	Ariella T. Cohain William T. Barrington Daniel M. Jordan Noam D. Beckmann Carmen A. Argmann Sander M. Houten Alexander W. Charney Raili Ermel Katyayani Sukhavasi Oscar Franzen Simon Koplev Carl Whatling Gillian M. Belbin Jialiang Yang Ke Hao Eimear E. Kenny Zhidong Tu Jun Zhu Li-Ming Gan Ron Do Chiara Giannarelli Jason C. Kovacic Arno Ruusalepp Aldons J. Lusis Johan L. M. Bjorkegren Eric E. Schadt
author_facet	Ariella T. Cohain William T. Barrington Daniel M. Jordan Noam D. Beckmann Carmen A. Argmann Sander M. Houten Alexander W. Charney Raili Ermel Katyayani Sukhavasi Oscar Franzen Simon Koplev Carl Whatling Gillian M. Belbin Jialiang Yang Ke Hao Eimear E. Kenny Zhidong Tu Jun Zhu Li-Ming Gan Ron Do Chiara Giannarelli Jason C. Kovacic Arno Ruusalepp Aldons J. Lusis Johan L. M. Bjorkegren Eric E. Schadt
author_sort	Ariella T. Cohain
title	An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
title_short	An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
title_full	An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
title_fullStr	An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
title_full_unstemmed	An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
title_sort	integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
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An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

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