A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to m...
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Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
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Nature Portfolio
2017
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Accès en ligne: | https://doaj.org/article/0c48607312374096801bf91f077ff9c0 |
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