A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to m...
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Nature Portfolio
2017
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oai:doaj.org-article:0c48607312374096801bf91f077ff9c02021-12-02T17:06:19ZA potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission10.1038/s41467-017-00572-x2041-1723https://doaj.org/article/0c48607312374096801bf91f077ff9c02017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00572-xhttps://doaj.org/toc/2041-1723Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes.David A. BakerLindsay B. StewartJonathan M. LargePaul W. BowyerKeith H. AnsellMaría B. Jiménez-DíazMajida El BakkouriKristian BirchallKoen J. DecheringNathalie S. BoulocPeter J. CoombsDavid WhalleyDenise J. HardingEla Smiljanic-HurleyMary C. WheldonEloise M. WalkerJohannes T. DessensMaría José LafuenteLaura M. SanzFrancisco-Javier GamoSantiago B. FerrerRaymond HuiTeun BousemaIñigo Angulo-BarturénAndy T. MerrittSimon L. CroftWinston E. GutteridgeCatherine A. KettleboroughSimon A. OsborneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David A. Baker Lindsay B. Stewart Jonathan M. Large Paul W. Bowyer Keith H. Ansell María B. Jiménez-Díaz Majida El Bakkouri Kristian Birchall Koen J. Dechering Nathalie S. Bouloc Peter J. Coombs David Whalley Denise J. Harding Ela Smiljanic-Hurley Mary C. Wheldon Eloise M. Walker Johannes T. Dessens María José Lafuente Laura M. Sanz Francisco-Javier Gamo Santiago B. Ferrer Raymond Hui Teun Bousema Iñigo Angulo-Barturén Andy T. Merritt Simon L. Croft Winston E. Gutteridge Catherine A. Kettleborough Simon A. Osborne A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| description |
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes. |
| format |
article |
| author |
David A. Baker Lindsay B. Stewart Jonathan M. Large Paul W. Bowyer Keith H. Ansell María B. Jiménez-Díaz Majida El Bakkouri Kristian Birchall Koen J. Dechering Nathalie S. Bouloc Peter J. Coombs David Whalley Denise J. Harding Ela Smiljanic-Hurley Mary C. Wheldon Eloise M. Walker Johannes T. Dessens María José Lafuente Laura M. Sanz Francisco-Javier Gamo Santiago B. Ferrer Raymond Hui Teun Bousema Iñigo Angulo-Barturén Andy T. Merritt Simon L. Croft Winston E. Gutteridge Catherine A. Kettleborough Simon A. Osborne |
| author_facet |
David A. Baker Lindsay B. Stewart Jonathan M. Large Paul W. Bowyer Keith H. Ansell María B. Jiménez-Díaz Majida El Bakkouri Kristian Birchall Koen J. Dechering Nathalie S. Bouloc Peter J. Coombs David Whalley Denise J. Harding Ela Smiljanic-Hurley Mary C. Wheldon Eloise M. Walker Johannes T. Dessens María José Lafuente Laura M. Sanz Francisco-Javier Gamo Santiago B. Ferrer Raymond Hui Teun Bousema Iñigo Angulo-Barturén Andy T. Merritt Simon L. Croft Winston E. Gutteridge Catherine A. Kettleborough Simon A. Osborne |
| author_sort |
David A. Baker |
| title |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| title_short |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| title_full |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| title_fullStr |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| title_full_unstemmed |
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission |
| title_sort |
potent series targeting the malarial cgmp-dependent protein kinase clears infection and blocks transmission |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0c48607312374096801bf91f077ff9c0 |
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