RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.

In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate translation in the presence of upstream nuclear factors. These RNA elements...

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Autores principales:	Kohila Mahadevan, Hui Zhang, Abdalla Akef, Xianying A Cui, Serge Gueroussov, Can Cenik, Frederick P Roth, Alexander F Palazzo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c5c8dfdf40543e787124ba6c96ece5e
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spelling	oai:doaj.org-article:0c5c8dfdf40543e787124ba6c96ece5e2021-11-18T05:37:08ZRanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.1544-91731545-788510.1371/journal.pbio.1001545https://doaj.org/article/0c5c8dfdf40543e787124ba6c96ece5e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23630457/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate translation in the presence of upstream nuclear factors. These RNA elements interact directly with, and likely co-evolved with, the zinc finger repeats of RanBP2/Nup358, which is present on the cytoplasmic face of the nuclear pore. Finally we show that RanBP2/Nup358 is not only required for the stimulation of translation by ALREX-promoting elements, but is also required for the efficient global synthesis of proteins targeted to the endoplasmic reticulum (ER) and likely the mitochondria. Thus upon the completion of export, mRNAs containing ALREX-elements likely interact with RanBP2/Nup358, and this step is required for the efficient translation of these mRNAs in the cytoplasm. ALREX-elements thus act as nucleotide platforms to coordinate various steps of post-transcriptional regulation for the majority of mRNAs that encode secreted proteins.Kohila MahadevanHui ZhangAbdalla AkefXianying A CuiSerge GueroussovCan CenikFrederick P RothAlexander F PalazzoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 11, Iss 4, p e1001545 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kohila Mahadevan Hui Zhang Abdalla Akef Xianying A Cui Serge Gueroussov Can Cenik Frederick P Roth Alexander F Palazzo RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
description	In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate translation in the presence of upstream nuclear factors. These RNA elements interact directly with, and likely co-evolved with, the zinc finger repeats of RanBP2/Nup358, which is present on the cytoplasmic face of the nuclear pore. Finally we show that RanBP2/Nup358 is not only required for the stimulation of translation by ALREX-promoting elements, but is also required for the efficient global synthesis of proteins targeted to the endoplasmic reticulum (ER) and likely the mitochondria. Thus upon the completion of export, mRNAs containing ALREX-elements likely interact with RanBP2/Nup358, and this step is required for the efficient translation of these mRNAs in the cytoplasm. ALREX-elements thus act as nucleotide platforms to coordinate various steps of post-transcriptional regulation for the majority of mRNAs that encode secreted proteins.
format	article
author	Kohila Mahadevan Hui Zhang Abdalla Akef Xianying A Cui Serge Gueroussov Can Cenik Frederick P Roth Alexander F Palazzo
author_facet	Kohila Mahadevan Hui Zhang Abdalla Akef Xianying A Cui Serge Gueroussov Can Cenik Frederick P Roth Alexander F Palazzo
author_sort	Kohila Mahadevan
title	RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
title_short	RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
title_full	RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
title_fullStr	RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
title_full_unstemmed	RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.
title_sort	ranbp2/nup358 potentiates the translation of a subset of mrnas encoding secretory proteins.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0c5c8dfdf40543e787124ba6c96ece5e
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RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.

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