Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle

A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of <i>Plasmodium</i>, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, its potency to suppress <i>...

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Autores principales: Helenita C. Quadros, Aysun Çapcı, Lars Herrmann, Sarah D’Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudêncio, Svetlana B. Tsogoeva, Diogo R. M. Moreira
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
malaria
<i>Plasmodium</i>
hemozoin
heterobivalent
artemisinin
hybrids
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/0c90374b919e4727a3854b15ff3c116b
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https://doaj.org/article/0c90374b919e4727a3854b15ff3c116b

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