Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcri...

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Autores principales: Zhiheng He, Jing Zhang, Zhaofeng Huang, Qian Du, Ning Li, Qiang Zhang, Yuan Chen, Zuoming Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0c98396d3fb04389a2b6fedc76057a5a
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