Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcri...

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Autores principales:	Zhiheng He, Jing Zhang, Zhaofeng Huang, Qian Du, Ning Li, Qiang Zhang, Yuan Chen, Zuoming Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c98396d3fb04389a2b6fedc76057a5a
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spelling	oai:doaj.org-article:0c98396d3fb04389a2b6fedc76057a5a2021-12-02T17:32:01ZSumoylation of RORγt regulates TH17 differentiation and thymocyte development10.1038/s41467-018-07203-z2041-1723https://doaj.org/article/0c98396d3fb04389a2b6fedc76057a5a2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07203-zhttps://doaj.org/toc/2041-1723The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcriptional activity of RORγt.Zhiheng HeJing ZhangZhaofeng HuangQian DuNing LiQiang ZhangYuan ChenZuoming SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiheng He Jing Zhang Zhaofeng Huang Qian Du Ning Li Qiang Zhang Yuan Chen Zuoming Sun Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
description	The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcriptional activity of RORγt.
format	article
author	Zhiheng He Jing Zhang Zhaofeng Huang Qian Du Ning Li Qiang Zhang Yuan Chen Zuoming Sun
author_facet	Zhiheng He Jing Zhang Zhaofeng Huang Qian Du Ning Li Qiang Zhang Yuan Chen Zuoming Sun
author_sort	Zhiheng He
title	Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
title_short	Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
title_full	Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
title_fullStr	Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
title_full_unstemmed	Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
title_sort	sumoylation of rorγt regulates th17 differentiation and thymocyte development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0c98396d3fb04389a2b6fedc76057a5a
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Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

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