Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhiheng He, Jing Zhang, Zhaofeng Huang, Qian Du, Ning Li, Qiang Zhang, Yuan Chen, Zuoming Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/0c98396d3fb04389a2b6fedc76057a5a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares