The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.

Human cytomegalovirus (CMV) exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes. Acute CMV infection results in transient restrictions in T cell proliferative ability, which can impair the control of the virus and increase the risk of seconda...

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Autores principales: Ildar Gabaev, Lars Steinbrück, Claudia Pokoyski, Andreas Pich, Richard J Stanton, Reinhard Schwinzer, Thomas F Schulz, Roland Jacobs, Martin Messerle, Penelope C Kay-Fedorov
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/0cb876d627b3413fb328cb0e678021eb
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