Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold

Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold

Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust scaffolds, and we characteri...

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Bibliographic Details
Main Authors: Fika Ayu Safitri, Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo, Dandan Zhao, Arief Budi Witarto, Sony Heru Sumarsono, Ernawati Arifin Giri-Rachman, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
guanine quadruplex
high-order structure
monomeric
immunostimulatory activity
adjuvant
Microbiology
QR1-502
Online Access:https://doaj.org/article/0cb9662d3dce41ee8d9804a7db7436e6
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https://doaj.org/article/0cb9662d3dce41ee8d9804a7db7436e6

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