Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism.

<h4>Background</h4>The monocled cobra (Naja kaouthia) is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A2 (PLA2; EC 3.1.1.4) is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s) for...

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Auteurs principaux: Ashis K Mukherjee, Bhargab Kalita, Rupamoni Thakur
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/0cbd1b1307b345c4b46d145117c26145
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