Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

Optical clearing of tissue has enabled optical imaging deeper into tissue due to significantly reduced light scattering. Here, Ryan et al. tackle first-order defocus, an artefact of a non-uniform refractive index, extending light-sheet microscopy to partially cleared samples.

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Detalles Bibliográficos
Autores principales: Duncan P. Ryan, Elizabeth A. Gould, Gregory J. Seedorf, Omid Masihzadeh, Steven H. Abman, Sukumar Vijayaraghavan, Wendy B. Macklin, Diego Restrepo, Douglas P. Shepherd
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0ce88ae2961c4eed9544d53128b6b9b0
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