Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

Optical clearing of tissue has enabled optical imaging deeper into tissue due to significantly reduced light scattering. Here, Ryan et al. tackle first-order defocus, an artefact of a non-uniform refractive index, extending light-sheet microscopy to partially cleared samples.

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Autores principales: Duncan P. Ryan, Elizabeth A. Gould, Gregory J. Seedorf, Omid Masihzadeh, Steven H. Abman, Sukumar Vijayaraghavan, Wendy B. Macklin, Diego Restrepo, Douglas P. Shepherd
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/0ce88ae2961c4eed9544d53128b6b9b0
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spelling oai:doaj.org-article:0ce88ae2961c4eed9544d53128b6b9b02021-12-02T14:42:08ZAutomatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy10.1038/s41467-017-00514-72041-1723https://doaj.org/article/0ce88ae2961c4eed9544d53128b6b9b02017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00514-7https://doaj.org/toc/2041-1723Optical clearing of tissue has enabled optical imaging deeper into tissue due to significantly reduced light scattering. Here, Ryan et al. tackle first-order defocus, an artefact of a non-uniform refractive index, extending light-sheet microscopy to partially cleared samples.Duncan P. RyanElizabeth A. GouldGregory J. SeedorfOmid MasihzadehSteven H. AbmanSukumar VijayaraghavanWendy B. MacklinDiego RestrepoDouglas P. ShepherdNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Duncan P. Ryan
Elizabeth A. Gould
Gregory J. Seedorf
Omid Masihzadeh
Steven H. Abman
Sukumar Vijayaraghavan
Wendy B. Macklin
Diego Restrepo
Douglas P. Shepherd
Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
description Optical clearing of tissue has enabled optical imaging deeper into tissue due to significantly reduced light scattering. Here, Ryan et al. tackle first-order defocus, an artefact of a non-uniform refractive index, extending light-sheet microscopy to partially cleared samples.
format article
author Duncan P. Ryan
Elizabeth A. Gould
Gregory J. Seedorf
Omid Masihzadeh
Steven H. Abman
Sukumar Vijayaraghavan
Wendy B. Macklin
Diego Restrepo
Douglas P. Shepherd
author_facet Duncan P. Ryan
Elizabeth A. Gould
Gregory J. Seedorf
Omid Masihzadeh
Steven H. Abman
Sukumar Vijayaraghavan
Wendy B. Macklin
Diego Restrepo
Douglas P. Shepherd
author_sort Duncan P. Ryan
title Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
title_short Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
title_full Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
title_fullStr Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
title_full_unstemmed Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
title_sort automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0ce88ae2961c4eed9544d53128b6b9b0
work_keys_str_mv AT duncanpryan automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT elizabethagould automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT gregoryjseedorf automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT omidmasihzadeh automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT stevenhabman automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT sukumarvijayaraghavan automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
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AT diegorestrepo automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
AT douglaspshepherd automaticandadaptiveheterogeneousrefractiveindexcompensationforlightsheetmicroscopy
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