Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

Most tumours are characterized by increased aerobic glycolytic activity. Here the authors show that elevated  aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate dehydrogenase depletion on the ability of hair follicle stem cells (HFSCs) to form squamous cell ca...

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Autores principales: A. Flores, S. Sandoval-Gonzalez, R. Takahashi, A. Krall, L. Sathe, L. Wei, C. Radu, J. H. Joly, N. A. Graham, H. R. Christofk, W. E. Lowry
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0d0df205d9034b698c8d903e3a5e6cc5
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