Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

Most tumours are characterized by increased aerobic glycolytic activity. Here the authors show that elevated aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate dehydrogenase depletion on the ability of hair follicle stem cells (HFSCs) to form squamous cell ca...

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Autores principales:	A. Flores, S. Sandoval-Gonzalez, R. Takahashi, A. Krall, L. Sathe, L. Wei, C. Radu, J. H. Joly, N. A. Graham, H. R. Christofk, W. E. Lowry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d0df205d9034b698c8d903e3a5e6cc5
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spelling	oai:doaj.org-article:0d0df205d9034b698c8d903e3a5e6cc52021-12-02T14:38:58ZIncreased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin10.1038/s41467-018-07857-92041-1723https://doaj.org/article/0d0df205d9034b698c8d903e3a5e6cc52019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07857-9https://doaj.org/toc/2041-1723Most tumours are characterized by increased aerobic glycolytic activity. Here the authors show that elevated aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate dehydrogenase depletion on the ability of hair follicle stem cells (HFSCs) to form squamous cell carcinoma (SCC) in mouse genetic models.A. FloresS. Sandoval-GonzalezR. TakahashiA. KrallL. SatheL. WeiC. RaduJ. H. JolyN. A. GrahamH. R. ChristofkW. E. LowryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Flores S. Sandoval-Gonzalez R. Takahashi A. Krall L. Sathe L. Wei C. Radu J. H. Joly N. A. Graham H. R. Christofk W. E. Lowry Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
description	Most tumours are characterized by increased aerobic glycolytic activity. Here the authors show that elevated aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate dehydrogenase depletion on the ability of hair follicle stem cells (HFSCs) to form squamous cell carcinoma (SCC) in mouse genetic models.
format	article
author	A. Flores S. Sandoval-Gonzalez R. Takahashi A. Krall L. Sathe L. Wei C. Radu J. H. Joly N. A. Graham H. R. Christofk W. E. Lowry
author_facet	A. Flores S. Sandoval-Gonzalez R. Takahashi A. Krall L. Sathe L. Wei C. Radu J. H. Joly N. A. Graham H. R. Christofk W. E. Lowry
author_sort	A. Flores
title	Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
title_short	Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
title_full	Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
title_fullStr	Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
title_full_unstemmed	Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
title_sort	increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0d0df205d9034b698c8d903e3a5e6cc5
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Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

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